Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1365531-89-0, is researched, Molecular C48H52O4P2, about Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides, the main research direction is catalytic asym conjugate addition thiolactam unsaturated thioamide; soft Lewis acid hard Bronsted base cooperative catalysis.SDS of cas: 1365531-89-0.
Direct catalytic asym. conjugate addition of thiolactams to α,β-unsaturated thioamides was efficiently promoted by a soft Lewis acid/hard Bronsted base cooperative catalyst in a highly stereocontrolled manner [e.g., I + II → III (anti/syn 97/3, >99% ee of anti)]. Thioamide functionality was crucial to promote both the efficient enolization of thiolactam pronucleophiles and the subsequent stereoselective conjugate addition to α,β-unsaturated thioamides. Differential manipulation of the two thioamide functionalities of the product highlights the synthetic utility of the present catalytic system.
As far as I know, this compound(1365531-89-0)SDS of cas: 1365531-89-0 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts