Zong, Cheng; Premasiri, Ranjith; Lin, Haonan; Huang, Yimin; Zhang, Chi; Yang, Chen; Ren, Bin; Ziegler, Lawrence D.; Cheng, Ji-Xin published the article 《Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity》. Keywords: adenine plasmon enhanced stimulated Raman scattering microscopy.They researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Product Details of 4556-23-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4556-23-4) here.
Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chem. imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ∼10 mM for endogenous biomols. Electronic pre-resonant SRS allows detection of sub-micromolar chromophores. However, label-free SRS detection of single biomols. having extremely small Raman cross-sections (∼10-30 cm2 sr-1) remains unreachable. Here, we demonstrate plasmon-enhanced stimulated Raman scattering (PESRS) microscopy with single-mol. detection sensitivity. Incorporating pico-Joule laser excitation, background subtraction, and a denoising algorithm, we obtained robust single-pixel SRS spectra exhibiting the statistics of single-mol. events. Single-mol. detection was verified by using two isotopologues of adenine. We further demonstrated the capability of applying PESRS for biol. applications and utilized PESRS to map adenine released from bacteria due to starvation stress. PESRS microscopy holds the promise for ultrasensitive detection of mol. events in chem. and biomedical systems.
There is still a lot of research devoted to this compound(SMILES：SC1=CC=NC=C1)Product Details of 4556-23-4, and with the development of science, more effects of this compound(4556-23-4) can be discovered.
Reference:
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