The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.Formula: C9H13NO2. The article 《Glutathione-reactive nitro compounds as radiosensitizers: mechanistic and therapeutic implications》 in relation to this compound, is published in International Journal of Radiation Oncology, Biology, Physics. Let’s take a look at the latest research on this compound (cas:4897-25-0).
Radiosensitization of Chinese hamster V79-379A cells to x-rays (1.93 Gy/min) by glutathione-reactive 4-nitroimidazoles is examined Sensitization efficiency increased with increasing nonprotein thiol depletion. Glutathione-nitroimidazole conjugate formation appeared to be correlated with thiol depletion. Sensitization with 5-chloro-1-methyl-4-nitroimidazole was studied, as well as with L-8711, Ro 31-0750, and Ro 21-7982. Therapeutic implications for tumor treatment are discussed.
If you want to learn more about this compound(5-Chloro-1-methyl-4-nitroimidazole)Formula: C4H4ClN3O2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(4897-25-0).
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts