Recommanded Product: 5-Chloro-1-methyl-4-nitroimidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Synthesis of 6-(1-methyl-4-nitro-5-[4,5-14C]-imidazolyl]thiopurine (azathioprine). Author is Yeowell, Heather N.; Elion, Gertrude B..
Steps in the radioactive synthesis are similar to those used in the preparation of unlabeled azathioprine. N,N’-Dimethyloxamide -1,2-14C was cyclized by PCl5 to I (labeled C located by asterisk) which was nitrated to II. Reaction of II with 6-mercaptopurine gave 85% III or 23.7% radioactive product.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts