So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Abrahamsson, K.; Andersson, P.; Bergman, J.; Bredberg, U.; Braanalt, J.; Egnell, A.-C.; Eriksson, U.; Gustafsson, D.; Hoffman, K.-J.; Nielsen, S.; Nilsson, I.; Pehrsson, S.; Polla, M. O.; Skjaeret, T.; Strimfors, M.; Wern, C.; Oelwegaard-Halvarsson, M.; Oertengren, Y. researched the compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid( cas:117918-23-7 ).Related Products of 117918-23-7.They published the article 《Discovery of AZD8165 – a clinical candidate from a novel series of neutral thrombin inhibitors》 about this compound( cas:117918-23-7 ) in MedChemComm. Keywords: human propionate prodrug thrombin inhibitor pharmacol response. We’ll tell you more about this compound (cas:117918-23-7).
A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions. This work resulted in the identification of the highly potent thrombin inhibitor compound 85 (Ki = 300 pM) and the corresponding propionate prodrug 5 (AZD8165) as a candidate for clin. evaluation in the treatment of thrombosis and related diseases. AZD8165 was found to be safe and well tolerated and delivered the expected pharmacol. response in a phase I trial in healthy male volunteers.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts