Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-2,2′-Bis[bis(3,5-dimethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy-)-1,1′-biphenyl, is researched, Molecular C48H52O4P2, CAS is 1365531-89-0, about Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration.Synthetic Route of C48H52O4P2.
1,4-Migrations of organopalladium and organorhodium species have been utilized for the development of various cascade reactions involving remote C-H bond activation. Recently, we reported a cobalt-catalyzed migratory arylzincation reaction of an alkyne that features alkenyl-to-aryl 1,4-cobalt migration and cobalt-to-zinc transmetalation as key steps. We report herein that the cobalt/arylzinc combination can also promote a cascade arylative cyclization reaction of alkynes bearing pendant ester or ketone moieties to afford benzo-fused cyclic ketone or alc. products, resp. The reaction is considered to proceed through insertion of the alkyne into an arylcobalt species, 1,4-cobalt migration, and intramol. organocobalt addition to the carbonyl group. The present cobalt/arylzinc system may not only serve as an alternative to previously reported rhodium/arylboron and iridium/arylboron systems but also complement their scopes in the arylative cyclization.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts