Heindel, Ned D.; Egolf, Roger A.; Stefely, James S. published an article about the compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0,SMILESS:C1=NC(=C(Cl)[N]1C)[N+]([O-])=O ).Electric Literature of C4H4ClN3O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4897-25-0) through the article.
A new class of radiosensitizing pharmaceuticals derived from 4-nitro-5-imidazolyl sulfones has its clin. potential compromised by a metabolic reaction with plasma glutathione which leads to a much less active metabolite. Entrapment of two members of the class in three different liposomes, one polymerized liposome, and a β-cyclodextrin system showed that this glutathione condensation can be suppressed by a rate factor of nearly 50-fold. Stabilizations of these metabolically labile radiosensitizers appear to relate to their lipid-buffer partition coefficients and to the fluidity of the liposome membrane in which they are entrapped.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts