The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Pyridine-4-thiol( cas:4556-23-4 ) is researched.SDS of cas: 4556-23-4.Tian, Huihui; Li, Hongbian; Fang, Ying published the article 《Binary Thiol-Capped Gold Nanoparticle Monolayer Films for Quantitative Surface-Enhanced Raman Scattering Analysis》 about this compound( cas:4556-23-4 ) in ACS Applied Materials & Interfaces. Keywords: thiol capped gold nanoparticle monolayer film SERS; gold nanoparticle; malachite green; monolayer film; quantitative SERS; self-assembly. Let’s learn more about this compound (cas:4556-23-4).
Surface-enhanced Raman scattering (SERS) can provide fingerprint information of analyte mols. with unparalleled sensitivity. However, quant. anal. using SERS has remained one of the major challenges owing to the difficulty of obtaining reproducible SERS substrates with high-d. hotspots. Here, we report the rational design and fabrication of a binary thiol-capped gold nanoparticle (AuNP) monolayer film (MLF) as a substrate for highly sensitive and quant. SERS anal. The two thiol ligands chem. bonded to the AuNPs play different roles: dodecanethiol with a long alkyl chain controls the interparticle gaps and electromagnetic coupling among AuNPs and 4-mercaptopyridine works as a Raman internal standard (IS). The binary thiol-capped AuNPs can self-assemble into an ordered MLF with high-d. hotspots and uniformly distributed IS. The as-prepared MLF has been demonstrated as a reliable SERS substrate for quant. detection of fungicide malachite green in aqueous solution, with a high enhancement factor (up to 3.3 × 107) and a low detection limit (100 pM). Moreover, the MLF SERS substrate is flexible and transparent, which has enabled in situ detection of trace fungicide residues in a shrimp tissue.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts