Month: September 2021

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4640-67-9 as follows. COA of Formula: C9H6FNO

1f (48.9mg, 0.3mmol), 1,2-dichloroethane (DCE, 1mL), 2-methyl-4-phenyl-3-butyne-2-ol (2a , 72.1mg, 0.45mmol),Dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer ([RhCp * Cl2] 2, 13.0mg, 0.021mmol) and CsOAc (57.6mg, 0.3mmol) will react in the air atmosphere The tube was sealed and the reaction was stirred at 100 C for 24 h. After the reaction, the reaction tube was cooled to room temperature, filtered with suction, and the mother liquor was mixed with silica gel and spin-dried, separated through a silica gel column (petroleum ether / ethyl acetate = 10/1) to obtain 3f (38.4 mg, 42%) as a yellow solid product.

According to the analysis of related databases, 4640-67-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Henan Normal University; Fan Xuesen; Song Xia; Zhang Xinying; (24 pag.)CN110746319; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-80-0, COA of Formula: C7H3ClN2O2

Example 1; Preparation of 4-(3,5-dimethylphenoxy)-3-(4-propionylpiperazin-l-ylsulfonyl)benzonitrile 57; [00201] Compound 57 was synthesized as shown in Scheme 2. Scheme 2 [00202] 4-(3,5-Dimethylphenoxy)-3-nitrobenzonitrile 21.; To a solution of 4-chloro-3- nitrobenzonitrile (12.00 g, 65.75 mmol) in THF was added potassium carbonate (45.58 g, 328.70 mmol) and 3,5-dimethylphenol (9.658 g, 78.88 mmol). The reaction mixture was refluxed for 17 hrs, whereupon the starting material was consumed (TLC, 25% EtOAc in hexanes). The reaction mixture was then cooled to room temperature, and potassium carbonate was filtered and washed with copious amounts of EtOAc. The filtrate was washed sequentially with saturated sodium bicarbonate solution, water, and saturated sodium chloride – 92 – SDI-13262vl solution, dried over anhydrous MgSO4, filtered, and concentrated in vacuo to give the crude product as a yellow solid. The solid was triturated with hexanes and filtered to afford compound 21 as a whitish-yellow powder. (15.022 g, 85.2% yield, 100 % HPLC purity). 1H NMR (500 MHz, DMSO-4): delta 8.65 (d, / = 2 Hz, IH), 8.06 (dd, J1 = 9 Hz, J2 = 2 Hz, IH), 7.12 (d, / = 9 Hz, IH), 6.97 (s, IH), 6.84 (s, 2H), 2.29 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; AXIKIN PHARMACEUTICALS, INC.; LY, Tai, Wei; FORRESTER, Jared, Andrew; WO2010/123960; (2010); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts