In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60899-34-5, name is 1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C10H7NO
a 4-Thiocarbamoyl-2,3-dihydro-1H-inden-1-one A solution of 12.1 g (77 mmol) of 4-cyano-2,3-dihydro-1H-inden-1-one ?see Coll. Czechoslov. Chem. Commun. 4, 3227[(1978)] in 220 ml of pyridine and 10.6 ml (77 mmol) of triethylamine is saturated with hydrogen sulfide for 3 hours at 40 and is then stirred at the same temperature for 16 hours. The reaction mixture is cooled and then concentrated to dryness by evaporation, and 300 ml of water are added to the residue. The yellow product that has crystallized out is filtered off with suction, washed with water, dried and recrystallized from ethyl acetate. In that manner there is obtained the title compound, m.p. 197 (decomp.).
The synthetic route of 60899-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novartis AG; US5840911; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts