Application of 17417-09-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17417-09-3 as follows.
Part A Preparation of 2-fluoro-5-aminobenzonitrile To a solution of 2-fluoro-5-nitrobenzonitrile (2.0 g, 12 mmol) in ethyl acetate(50 mL) was added stannous chloride (27.0 g, 120 mmol). The reaction mixture was stirred at reflux 1.5 h, then cooled to room temperature. Partitioned between ethyl acetate (150 mL) and saturated sodium bicarbonate(150 mL). Organic phase was separated and washed with water (5*75 mL), brine (75 mL); dried over sodium sulfate (anhy.); filtered and concentrated to give 2-fluoro-5-aminobenzonitrile (1.4 g) as pure compound.
According to the analysis of related databases, 17417-09-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DuPont Pharmaceuticals Company; US6020357; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts