Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, Recommanded Product: 127946-77-4
Example 2; Synthesis of N-(1-cyanocyclopropyl)-2(S)-(1-benzenesulfonyliminoethylamino)-3 -(1-methyl-cyclohexyl)propionamide; (table 2, cpd 19); Step 1; To a stirred solution of 2S-fc^butoxycarbonylamino-3-(l-methylcyclohexyl)propionicacid (283 rng, 1.0 mmol) (prepared as described in Reference H except utilizing 1-methylcyclohexanol intead of 1-methylcyclopentanol) and 1-aminocyclopropanecarbonitrileHC1 salt (178 mg, 1.5 mmol) in DMF (5 mL) at room temperature was added HATU (418 mg,1.1 mmol), followed by diisopropyl ethylamine (0.87 mL, 5 mmol). After being stirred at roomtemperature overnight, the reaction mixture was concentrated under reduced pressure and thenpartitioned between ethyl acetate and brine. The combined organic extracts were dried (MgSCX),concentrated under reduced pressure, and the residue was purified by flash chromatography onsilica gel (eluted with 1: 2 EtOAc/ hexanes) to yield [l-(l-cyanocyclopropylcarbamoyl)-25′-(l-methylcyclohexyl)ethyl]-carbamic acid tert-butyl ester (315 mg, 90%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AXYS PHARMACEUTICALS; WO2004/108661; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts