Application of 6393-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6393-40-4 name is 4-Amino-3-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-amino-3-nitrobenzonitrile (1.0 eq) was reacted with 2,5-dimethoxy- tetrahydrofuran (1.0 eq) in acetic acid. The reaction was heated in a microwave oven at 160ºC for 10 min. The solvent was evaporated and the residue purified by flash chromatography on silica gel (hexanes/EtOAc gradient). 3-nitro-4-(1H-pyrrol-1-yl)benzonitrile was obtained as an orange-yellow solid (59% yield). LCMS (ES): >;95% pure, m/z 214 [M+l]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-3-nitrobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; CYLENE PHARMACEUTICALS, INC.; PIERRE, Fabrice; HADDACH, Mustapha; CHUA, Peter, C.; WO2010/135571; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts