Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 38487-86-4
Cyclohexanone (36mL), 2-amino-4-chlorobenzonitrile (4.6g, 30mmol) and zinc chloride (4.1g, 30mmol) were mixed in a flask and the mixture was heated to 120C for 3h. Following cooling to room temperature and evaporation of the solvent, the residue was diluted with ethyl acetate (30mL) and the solid was collected by filtration. A 10% aqueous solution of NaOH (50mL) was added. After stirring for 2h, the mixture was filtered, and the filter cake was washed with water and extracted with methanol. The combined extracts were concentrated to afford the desired product (4.7g) in 67% yield. 1H NMR (400MHz, DMSO) delta 8.17 (d, J=9.0Hz, 1H), 7.62 (d, J=2.0Hz, 1H), 7.28 (s, 1H), 6.46 (s, 2H), 2.81 (d, J=5.5Hz, 2H), 2.52 (s, 2H), 1.80 (d, J=4.7Hz, 4H). LC/MS (ESI): m/z 233.2 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Sun, Yang; Chen, Jianwen; Chen, Xuemin; Huang, Ling; Li, Xingshu; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7406 – 7417;,
Nitrile – Wikipedia,
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