Related Products of 874-97-5, These common heterocyclic compound, 874-97-5, name is 3-Cyanobenzyl alcohol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound of Reference Example 1 3- (hydroxymethyl) benzonitrile (0.043 mL, 0.37 mmol) and sodium hydride (17 mg, 0.40 mmol) were added to a DMF (0.32 mL) solution of sodium hydride (50 mg, 0.16 mmol) And the mixture was stirred at 100 C. for 14 hours. Water (10 mL) was added to the reaction mixture at room temperature and extracted with ethyl acetate (10 mL × 2). The organic layers were combined, dried over sodium sulfate and concentrated. The resulting concentrate was purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 30/70) to give the intermediate as a yellow oil (48 mg).To a solution of the obtained intermediate (48 mg) in 1,4-dioxane (0.32 mL) was added 4 N hydrogen chloride 1,4-dioxane solution (0.80 mL) at room temperature, and the mixture was stirred at room temperature for 2 hours. Acetonitrile (2.0 mL) was added to the reaction mixture at room temperature, diethyl ether (4.0 mL) was added dropwise at room temperature, and the mixture was stirred at room temperature for 1 hour. The solid was collected by filtration and dried under reduced pressure at room temperature to give 3 – (((6- (1,4-diazepan-1 -yl) pyrazin-2-yl) oxy) methyl) benzonitrile dihydrochloride Compound of Example 5) as a white solid (43 mg, yield 70%).
The synthetic route of 874-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TORAY INDUSTRIES INCORPORATED; KIKUCHI, TSUKASA; OKANO, TSUBASA; (24 pag.)JP2017/14121; (2017); A;,
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