Electric Literature of 20099-89-2,Some common heterocyclic compound, 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, molecular formula is C9H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A vial containing a mixture of 2-aminopyridine (1) (1 mmol), and alpha-bromoketone (2) (1 mmol) was placed in a microwave synthesiser. The vial was subjected to microwave irradiation programmed at 65 C, 120 W and 1 bar pressure. After 15-20 min of irradiation, the mixture was cooled to room temperature. The crude product (3) was subjected to column chromatography on alumina (solvent: dichloromethane) to obtain the pure products.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(2-Bromoacetyl)benzonitrile, its application will become more common.
Reference:
Article; Kong, Dulin; Wang, Xianghui; Shi, Zaifeng; Wu, Mingshu; Lin, Qiang; Wang, Xin; Journal of Chemical Research; vol. 40; 9; (2016); p. 529 – 531;,
Nitrile – Wikipedia,
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