Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17626-40-3, name is 3,4-Diaminobenzonitrile, A new synthetic method of this compound is introduced below., name: 3,4-Diaminobenzonitrile
In a round bottom flask (250ml) 3,4-dichloro-1-(hexadecan-6-yl)-1H-pyrrole-2,5-dione (10g, 25.6 mmol) wasdissolved under argon in 150ml of absolute ethanol. Sodium acetate (2.5g, 30.7mmol) and 3,4-diaminobenzonitrile (3.4g,25.6 mmol) were added. The mixture was stirred overnight at room temperature. Ethanol was removed by distillationunder vacuum at 40C and the crude product was purified by flash chromatography onto silica gel using hexane/methylene-chloride/ethylacetate 60/35/5 as the eluent. 2.5g of pure product were obtained as yellow wax with a yield of 21%. When conditions were made harsher by heating to reflux the final product (5) was obtained (yield 40%).
The synthetic route of 17626-40-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Solvay SA; Caille, Jean-Raphael; Dabeux, Francois; Bolsee, Jean-Christophe; Fenoll, Mathieu; EP2808327; (2014); A1;,
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