Reference of 2973-50-4, These common heterocyclic compound, 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In an Erlenmeyer flask, 2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazide (4) (1.0 mmol), aromatic nitriles (1.0 mmol) and DMAP (30 mol%) were taken in ethanol (15 mL). The reaction mixture was irradiated inside a synthetic microwave oven (Make-Ethosi Milestone with temperature control) for about 20-25 min (700 W). After completion of reaction (monitored by TLC), the mixture was concentrated to obtain the solid product. The solid product formed was filtered, dried and recrystallized from ethanol.
Statistics shows that 2-(2-Aminophenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 2973-50-4.
Reference:
Article; Sangshetti, Jaiprakash N.; Kalam Khan, Firoz A.; Chouthe, Rashmi S.; Damale, Manoj G.; Shinde, Devanand B.; Chinese Chemical Letters; vol. 25; 7; (2014); p. 1033 – 1038;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts