Electric Literature of 77326-36-4,Some common heterocyclic compound, 77326-36-4, name is 2-Amino-6-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sodium hydride (0.154 g, 3.85 mmol, 1.5 equiv) was added to a mixture of 2-amino-6-fluorobenzonitrile (0.524 g, 3.85 mmol, 1.5 equiv) and 2-methyl-2-((5-methylpyrimidin-2-yl)amino)propan-1-ol (Example 1b, 0.465 g,2.56 mmol, 1 equiv) in anhydrous THF (25 mL) under nitrogen. The reaction mixture was stirred for 10 minutes at room temperature and refluxed for 21 h. The reaction mixture was concentrated and the residue was purified by chromatography on a silica(50% EtOAc in Hexanes gradient) to provide the title compound (611 mg, 80% yield), MS 298 (MH+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-6-fluorobenzonitrile, its application will become more common.
Reference:
Patent; FIRMENICH INCORPORATED; FOTSING, Joseph, R.; TACHDJIAN, Catherine; SERVANT, Guy; CHING, Brett, Weylan; DAVIS, Timothy; (94 pag.)WO2020/33420; (2020); A1;,
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