Application of 14447-18-8, A common heterocyclic compound, 14447-18-8, name is Benzyl cyanoacetate, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4b (0.30 g, 1.15 mmol) and 6a (0.24 g, 1.38 mmol) were dissolved in tetrahydrofuran (10 mL). Piperidine (11 muL, 0.11 mmol) was then dissolved and stirred at 50 C. for 10 hours. After the reaction was completed, the mixture was cooled at room temperature and extracted with ethyl acetate. The organic solvent layer was collected, and water was removed with magnesium sulfate, followed by concentration under reduced pressure. The resulting concentrate was purified by silica gel column chromatography (hexane: acetone: ethyl acetate = 3: 1: 1) to give compound 8a in 65% yield in the form of a purple powder.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Konkuk University Industry-Academic Cooperation Foundation; Jung, Yoo Hoon; Park, Kwang Soo; So, Yoo Jin; (14 pag.)KR101728909; (2017); B1;,
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