9/3/2021 News Sources of common compounds: 3598-13-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Chlorophenoxy)acetonitrile, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 3598-13-8, name is 2-(4-Chlorophenoxy)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3598-13-8, HPLC of Formula: C8H6ClNO

2-(3-(hydroxymethyl)-6-nitro-2,3-dihydrobenzo[b][l,4]dioxin-5-yl)acetonitrile: A solution of racemic (7-nitro-2,3-dihydrobenzo[b][l,4]dioxin-2-yl)methanol (1.00 g, 4.73 mmol) and 4-chlorophenoxyacetonittauile (827 mg, 4.94 mmol) in DMF (12 mL) was added dropwise to a solution of potassium tert-butoxide (2.12 g, 18.9 mmol) in DMF (20 mL) at -5- 00C. After the addition was complete (7 minutes), the reaction mixture was stirred for 1 hour at -5-00C. The reaction mixture was acidified with 1 N HCl before drowning into water (200 mL). The mixture was extracted with EtOAc (3 x 100 mL) and the combined organic layers were washed with IN NaOH (3 x 50 mL) to remove most of the 4-chlorophenol. After removal of solvent, the residue was purified by flash chromatography on silica gel, gradient elution using 2:3, 1 :1, 3:2, 100:0 ethyl acetate/hexane, to give 139 mg, 14% recovered starting material and 804 mg, 68% yield of the title compound as a solid. 1H NMR (CDCl3) 5 7.77 (IH, d, J=9.12 Hz); 7.01 (IH, d, J=9.12 Hz); 4.50-4.40 (2H, m); 4.30-3.91 (5H, m); 2.25-2.21 (IH, m). 13C NMR (CDCl3) 5 148.07, 141.71, 141.55, 119.44, 117.07, 116.96, 115.71 , 74.36, 65.31, 61.18, 14.89.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Chlorophenoxy)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WYETH; WO2007/139998; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts