In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 78473-00-4, name is 4-Amino-3,5-dichlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H4Cl2N2
nto a 1000 mL three-neck flask were put 9.4 g (50 mmol) of 4-amino-3,5-dichlorobenzonitrile, 26 g (253 mmol) of isobutylboronic acid, 54 g (253 mmol) of tripotassium phosphate, 2.0 g (4.8 mmol) of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (S-phos), and 500 mL of toluene. The atmosphere in the flask was replaced with nitrogen, and this mixture was degassed while being stirred under reduced pressure. After the degassing, 0.88 g (0.96 mmol) of tris(dibenzylideneacetone)palladium(0) was added, and the mixture was stirred under a nitrogen stream at 130 C. for 8 hours to be reacted. Toluene was added to the obtained reacted solution, and the mixture was filtered through a filter aid in which Celite (Catalog No. 531-16855, manufactured by Wako Pure Chemical Industries, Ltd. (the same applies to Celite in the following description)), aluminum oxide, and Celite were stacked in this order. the obtained filtrate was concentrated to give an oily substance. The obtained oily substance was purified by silica column chromatography. Toluene was used as a developing solvent. The resulting fraction was concentrated to give 10 g of a yellow oily substance in a yield of 87%. The obtained yellow oily substance was identified as 4-amino-3,5-diisobutylbenzonitrile by nuclear magnetic resonance (NMR).
The synthetic route of 78473-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; Watabe, Takeyoshi; Watabe, Satomi; Yoshizumi, Hideko; Hara, Tomoka; Yamada, Yui; Ishisone, Takahiro; Kido, Hiromitsu; Suzuki, Kunihiko; Seo, Satoshi; (88 pag.)US2018/62084; (2018); A1;,
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