Adding a certain compound to certain chemical reactions, such as: 1572-52-7, name is 2-Methylenepentanedinitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1572-52-7, Product Details of 1572-52-7
(0099) At 0 C., 8.96 g (56.07 mmol) of bromine are slowly added dropwise to a solution of 7.0 g (65.96 mmol) of 2-methylenepentanedinitrile. The reaction mixture is then stirred at 35 C. for 2 hours. The reaction mixture is then once more cooled to 0 C., and 6.52 g (85.75 mmol) of 1-hydroxyurea are added. A solution of 7.13 g (178.09 mmol) of NaOH in 15 ml of water is then slowly added dropwise at 0 C., and the mixture is boiled under reflux for 3.5 hours. The solvents are concentrated and the residue is then dissolved in 20 ml of water and extracted three times with in each case 10 ml of dichloromethane. The combined organic phases are dried over sodium sulfate and concentrated. Yield: 2.8 g (29%). (0100) 1H-NMR, DMSO-d6, 400 MHz: 8.24 (s, 1H), 5.56 (bs, 2H), 2.71 (t, 2H), 2.60 (t, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methylenepentanedinitrile, and friends who are interested can also refer to it.
Reference:
Patent; BAYER CROPSCIENCE AG; KOEHN, Arnim; AHRENS, Hartmut; BRAUN, Ralf; HEINEMANN, Ines; TIEBES, Joerg; WALDRAFF, Christian; DIETRICH, Hansjoerg; GATZWEILER, Elmar; ROSINGER, Christopher Hugh; SCHMUTZLER, Dirk; US2015/307462; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts