Application of 3215-64-3, The chemical industry reduces the impact on the environment during synthesis 3215-64-3, name is 2-(2,6-Dichlorophenyl)acetonitrile, I believe this compound will play a more active role in future production and life.
Alternative Conditions. To a solution of sodium (169 mg, 7.35 mmol) dissolved in 2-ethoxyethanol (7.0 mL) was added 2,6-dichlorophenylacetonitrile (1.40 g, 7.53 mmol) and (IV) (502 mg, 3.66 mmol), and the mixture was then stirred at reflux for 30 minutes. The resulting solution was diluted with aqueous NaHCO3 (50 mL) and extracted with EtOAc (3*50 mL). The solvents were removed under reduced pressure, then chromatography of the residue on silica gel, eluding with 2-3% MeOH/CH2 Cl2, gave firstly a mixed fraction, which on crystallisation from CHCl3 /light petroleum gave 2,6-dichlorophenylacetamide (165 mg): mp (MeOH/CH2 Cl2) 211.5-213 C. 1 H NMR [(CD3)2 SO] delta 7.53 (br s, 1H, NH), 7.44 (d, J=8.1 Hz, 2H, H-3,5), 7.30 (dd, J=8.5, 7.6 Hz, 1H, H-4), 7.02 (br s, 1H, NH), 3.77 (s, 2H, CH2). 13 C NMR delta 169.60 (s, CONH2), 135.56 (s, 2 C, C-2,6), 132.67 (s, C-1), 129.22 (d, C-4), 128.09 (d, 2 C, C-3,5), 37.31 (t, CH2). Analysis calculated for C8 H7 Cl2 NO) requires: C, 47.1; H, 3.4; N, 6.9% Found: C, 47.3; H, 3.5; N, 7.1%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2,6-Dichlorophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Warner-Lambert Company; US6150359; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts