In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4640-67-9 as follows. COA of Formula: C9H6FNO
1f (48.9mg, 0.3mmol), 1,2-dichloroethane (DCE, 1mL), 2-methyl-4-phenyl-3-butyne-2-ol (2a , 72.1mg, 0.45mmol),Dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer ([RhCp * Cl2] 2, 13.0mg, 0.021mmol) and CsOAc (57.6mg, 0.3mmol) will react in the air atmosphere The tube was sealed and the reaction was stirred at 100 C for 24 h. After the reaction, the reaction tube was cooled to room temperature, filtered with suction, and the mother liquor was mixed with silica gel and spin-dried, separated through a silica gel column (petroleum ether / ethyl acetate = 10/1) to obtain 3f (38.4 mg, 42%) as a yellow solid product.
According to the analysis of related databases, 4640-67-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Henan Normal University; Fan Xuesen; Song Xia; Zhang Xinying; (24 pag.)CN110746319; (2020); A;,
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