Reference of 6011-14-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6011-14-9 as follows.
General procedure: For the aryl alpha-iminonitriles, a suspension of aminoacetonitrile hydrochloride (0.37 g, 4.0 mmol) and Et3N (1.0 mL, 7.2 mmol) in ethanol (10 mL) was stirred at room temperature for 0.5 h. To the resulting solution was added the corresponding aldehyde (2.0 mmol). After the reaction mixture was stirred for 1-2 h, the solvent was removed in vacuo. The residue was then diluted with EtOAc and washed with brine, dried over MgSO4, filtered and concentrated under in vacuo. The crude alpha-iminonitrile was used in next step without further purification.
According to the analysis of related databases, 6011-14-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Li, Jundong; Lin, Na; Yu, Lei; Zhang, Yandong; Tetrahedron Letters; vol. 57; 51; (2016); p. 5777 – 5780;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts