Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96606-37-0, name is 2,4,6-Trifluorobenzonitrile, A new synthetic method of this compound is introduced below., name: 2,4,6-Trifluorobenzonitrile
NaH (60% in mineral oil, 1.21g, 30.3 mmol) was added in one portion to (E)-2-Buten-1-ol (1.62g, 20 mmol) in 20 ml THF with cooling from an ice water bath. The mixture was stirred for 10 min, then added dropwise to 2,4,6-trifluorobenzonitrile (3.2 g, 20 mmol) in 20ml THF, with cooling from an ice bath. The solution was stirred at room temperature for 4 hours, then quenched with acetic acid. This solution was dried onto silica gel and purified by normal phase chromatography using an ISCO Combiflash, eluted with ethyl acetate and hexane. Yield (3.2g, 80% yield). 1H NMR (300 MHz, CDCl3) delta 6.53(m, 2H) 5.93(m, 1H) 5.73(m, 1H) 4.60(m, 2H) 1.81(d, J=6Hz, 3H). LC/MS, 210.2 [M+H]+ calculated 210.2
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CIDARA THERAPEUTICS, INC.; BALKOVEC, James, Michael; BENSEN, Daniel, C.; BORCHARDT, Allen; BRADY, Thomas, Patrick; CHEN, Zhi-yong; LAM, Thanh; TARI, Leslie, W.; (204 pag.)WO2016/201219; (2016); A1;,
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