Application of 194853-86-6, These common heterocyclic compound, 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Weigh 508mg of 5,5-dimethylhein into eggplant-shaped bottles, add 5mL of DMF with stirring to completely dissolve it, then add 220mg of K2CO3 (1eq), stir at 45 C for half an hour to make them mix well. Finally, the DMF solution of 4-fluoro-2-trifluoromethylbenzonitrile (300 mg) was slowly added, and stirred under heating for 5 hours. After the reaction was fully completed, it was cooled to room temperature and diluted with 30 mL of ethyl acetate. It was extracted 3 times with 20 mL of saturated ammonium chloride aqueous solution and once with saturated brine. The organic layer was dried over anhydrous magnesium sulfate for 6 h, filtered with suction, and concentrated. Finally, 200-300 mesh column chromatography was performed to obtain 330 mg of a white solid. Yield 79%.
The synthetic route of 194853-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhengzhou University; Ke Yu; Xie Hang; Liu Hongmin; Xu Xia; Liang Jianjia; (25 pag.)CN110759897; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts