Continuously updated synthesis method about 67832-11-5

Statistics shows that 4-Bromo-2-methylbenzonitrile is playing an increasingly important role. we look forward to future research findings about 67832-11-5.

Reference of 67832-11-5, These common heterocyclic compound, 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of 6-bromo-l -chlorophthalazine (18) Step A: A mixture of 4-bromo-2-methylbenzonitrile (14, 22 g, 112 mraol), benzoyl peroxide (2.7 g, 11 mmol) in 400 mL carbon tetrachloride was treated with n- bromosuccimide (21 mL, 247 mmol) at RT, then warmed up to 90 0C and stirred for 15 h. After 15 h of reaction, another 20 g of NBS was added and the reaction was stirred at 90 0C for another 1O h. Thin layer chromatography (TLC) revealed that all the starting material had been consumed. The reaction was cooled down to RT, filtered, and washed with hexane (100 mL). The filtrate was concentrated in vacuo, and the crude product was purified via flash chromatography (silica gel) eluting with a gradient of 4/1 hexanes/EtOAc to 2/1 hexanes/EtOAc, to give as a white solid, 4-bromo-2- (dibromomethyl)benzonitrile IS, 29.6g. Found MS (ES+): 354 (M+H)+.

Statistics shows that 4-Bromo-2-methylbenzonitrile is playing an increasingly important role. we look forward to future research findings about 67832-11-5.

Reference:
Patent; AMGEN INC.; TASKER, Andrew; ZHANG, Dawei; WO2008/30466; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts