Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 66389-80-8, name is tert-Butyl 4-cyanobenzylcarbamate, A new synthetic method of this compound is introduced below., HPLC of Formula: C13H16N2O2
General procedure: To a round-bottom flask equipped with a stir bar was added 28a-b (1.0 eq), hydroxylamine hydrochloride (2.0 eq), NaHCO3 (4.0 eq), and methanol (10 mL/mmol). The reaction was refluxed and stirred in a pre-heated 75 C. oil-bath for 6 h. After cooling to room temperature, the precipitate was filtered off and washed with methanol. The filtrate was concentrated in vacuo and further purified on a silica gel column. Example 89 Synthesis of 215 tert-Butyl (E)-(4-(N?-hydroxycarbamimidoyl)benzyl) carbamate (29a) (0246) The synthesis follows the general procedure described in Example 88. Yield: 65%. MP: 142-145 C. 1H NMR (400 MHz, DMSO-d6) delta 9.57 (s, 1H, -OH), 7.61 (d, J=8.1 Hz, 2H, -ArH), 7.40 (t, J=6.1 Hz, 1H, -NHCO-), 7.22 (d, J=8.1 Hz, 2H, -ArH), 5.77 (s, 2H, -NH2), 4.13 (d, J=6.1 Hz, 2H, -ArCH2-), 1.40 (s, 9H, -CH3).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Washington University; Tu, Zhude; Rosenberg, Adam; Liu, Hui; Han, Junbin; US2019/2450; (2019); A1;,
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