Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2469-99-0, name is 3-Oxobutanenitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Oxobutanenitrile
Step 1. 2-Benzylidene-3-oxobutanenitrile Into a 100-mL round-bottom flask, was placed a solution of 3-oxobutanenitrile (4.15 g, 50.00 mmol, 1.00 equiv) in toluene (50 mL), benzaldehyde (5.3 g, 50.00 mmol, 1.00 equiv), piperidine (430 mg, 5.06 mmol, 0.10 equiv), and acetic acid (600 mg, 10.00 mmol, 0.20 equiv). The resulting solution was heated to reflux for 8 hr. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:10). This resulted in 2.3 g (24%) of 2-benzylidene-3-oxobutanenitrile as a yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BIOENERGENIX; US2012/277224; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts