151-18-8, name is 3-Aminopropanenitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 151-18-8
To a 3-neck round-bottom flask wasadded (S)-3-[5-(3,4-dichloro-phenyl)-1 -(4-methoxy-phenyl)-1 H-pyrazol-3-yl]-2-25 m-tolyl-propionic acid (Example 1; 5.0 g, 9.9 mmol, 1.0 equiv), EDC (4.7 g, 24.7 mmol, 2.5 equiv) and HOST (3.3 g, 24.7 mmol, 2.5 equiv) under nitrogen.A/,A/-Dimethylformamide (50 ml) was added, followed by 3-aminopropanenitrile(1.9 g, 24.7 mmol, 2.5 equiv) and diisopropylethylamine (6.8 ml, 39.6 mmol,4.0 equiv). The reaction mixture was stirred overnight, then was diluted with5 ethyl acetate (200 ml), washed with 1 N HCI (100 ml), H2O (100 mL),10%sodium bicarbonate (100 ml), H2O (100 ml) then brine (100 ml), and dried(sodium sulfate). The solvent was then removed under reduced pressureyielding the desired amide (5.35 g, 99%), which was used in the next stepwithout purification. HPLC: Rt = 7.89 (Method A). MS (ESI): mass calculated10 for C29H26Cl2N4O2, 532.14; m/zfound, 533.3 [M+H]+. 1H NMR (500 MHz,CDCI3): 7.31-7.30 (m, 2H), 7.23 (t, J= 7.4 Hz, 1H), 7.19 (br s, 1H), 7.16-7.14(m, 3H), 7.10 (d, J= 7.4 Hz, 1H), 6.91 (dd, J = 8.5, 2.2 Hz, 1H), 6.87 (d, J= 9.0Hz, 2H), 6.20 (s, 1H), 6.09 (t, J = 6.0 Hz, 1H), 3.90 (dd, J = 9.0, 6.0 Hz, 1H),3.82 (s, 3H), 3.56-3.50 (m, 2H), 3.35-3.31 (m, 1H), 3.08 (dd, J = 14.8, 6.0 Hz,15 1 H), 2.53-2.46 (m, 2H), 2.35 (s, 3H).
The synthetic route of 151-18-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/5393; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts