These common heterocyclic compound, 139152-08-2, name is 4,5-Dichlorophthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4,5-Dichlorophthalonitrile
0.30 g(1.5 mmol) of 4,5-dichlorophthalonitrile and 0.28 g(3.0 mmol) of phenol preliminarily crystallized fromhexane were dissolved in 15 mL of DMF and asolution of 0.42 g (3 mmol) of potassium carbonate in1 mL water was added. The reaction mixture wasstirred at 80-90 for 12 h, then the target product wasfiltered off, washed with hot water till the smell ofphenol ceased, and dried at 80-90. Yield 0.26 g(82%). Found, %: C 76.38; H 3.98; N 8.72. C20H12N22.Calculated, %: C 76.91; H 3.87; N 8.97.
The synthetic route of 4,5-Dichlorophthalonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Znoiko; Petlina; Shaposhnikov; Smirnov; Russian Journal of General Chemistry; vol. 88; 6; (2018); p. 1148 – 1153; Zh. Obshch. Khim.; vol. 88; 6; (2018); p. 968 – 973,6;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts