Synthetic Route of 103146-25-4, A common heterocyclic compound, 103146-25-4, name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, molecular formula is C20H23FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 50 GMS OF 4- [4- (DIMETHYLAMINO)-1- (4 -FLUOROPHENYL)-1-HYDROXYBUTYL]-3 (HYDROXYMETHYL) – benzonitrile (cyano diol) was added to a mixture of 50 gm phosphoric acid and 150 gm water. The mixture was heated to 105C for 14 hours. The reaction mixture was cooled to 40C and diluted with 1000 ml water. The pH of the solution was adjusted to 8-10 with liquor ammonia and extracted with ethyl acetate. The ethyl acetate layer was washed with 50 ML of 5% disodium edetate solution twice to remove the carboxamide impurity (about 3%) and the cyano diol impurity (about 0.8%). The ethyl acetate layer was dried over sodium sulphate, treated with decolorizing charcoal and filtered. The solution was acidified to a pH between 3-3.5 with 48% aqueous hydrobromic acid. The precipitated product of citalopram hydrobromide was filtered. This product had a purity of greater than 99.85%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MEDITAB SPECIALITIES PVT. LTD; WAIN, Christopher, Paul; WO2005/12278; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts