Application of 64248-62-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64248-62-0 as follows.
In a 500mL three-necked flask,Add 3,4-difluorobenzonitrile (50.0 g, 0.28 mol)And 200mL of absolute ethanol,Control temperature 0~5 C,Pass dry HCl gas to saturation,The reaction was kept for 30 hours, a large amount of white solid was precipitated, and suction filtration was applied. The filter cake was washed with 0 to 5 C anhydrous ethanol, and dried under vacuum to give (VI-11) 52.5 g, yield 65.9%.
According to the analysis of related databases, 64248-62-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Pharmaceutical University; Hefei Medical Engineering Pharmaceutical Co., Ltd.; Xu Yungen; He Guangwei; Liu Kun; Chu Zhaoxing; Zhu Qihua; Zhao Yan; Liu Weizhong; Wang Kui; Zhang Luyong; (26 pag.)CN108456152; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts