Some common heterocyclic compound, 5922-60-1, name is 2-Amino-5-chlorobenzonitrile, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 5922-60-1
Example 3: Synthesis of 6-chloro-2,4-diamino-quinazolineA mixture of 2-amino-5-chlorobenzonitrile (1.07 g, 7.0 mmol), chloro- formamidine hydrochloride (1.6 g, 14 mmol), sulfolane (0.5 ml) and dimethylsulfone(3 g) was heated at 165 0C for 30 minutes. Then, water (30 ml) was added to the reaction mixture. The pH was adjusted to 7-8 by the addition of a 33 percent aqueous ammonia solution in water. The precipitate was collected by filtration, washed with water and dried over P2O5, yielding the title compound as a yellowish solid (1.35 g, yield: 99 percent) which was characterized by its mass spectrum as follows: MS (m/z): 195([M+H]+, 100).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5922-60-1, its application will become more common.
Reference:
Patent; GILEAD SCIENCES, INC.; WO2008/9077; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts