Related Products of 52798-01-3, A common heterocyclic compound, 52798-01-3, name is Methyl (4-cyanophenyl)acetate, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a. Methyl 2-(4-cyanophenyl)-tert.butyl malonate 1.7 g (0.01 mol) of methyl 4-cyanophenylacetate are dissolved in 30 ml tetrahydrofuran, 0.48 g (0.01 mol) of sodium hydride (60% in oil) are added in batches thereto and stirred for 15 minutes at 60 C. Then 1.5 ml (0.01 mol) of tert.butyl bromoacetate are added dropwise at ambient temperature. The reaction mixture is refluxed for 5 hours, cooled and poured onto water and extracted with methylene chloride. The combined organic extracts are dried and evaporated down. The residue is chromatographed on silica gel and eluted with petroleum ether/ethyl acetate (4:1). Yield: 1.5 g (52% of theory), Rf value: 0.7 (silica gel; petroleum ether/ethyl acetate=7:3).
The synthetic route of 52798-01-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Ingelheim Pharma KG; US6114532; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts