Related Products of 16588-02-6,Some common heterocyclic compound, 16588-02-6, name is 2-Chloro-5-nitrobenzonitrile, molecular formula is C7H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Conc. HC1 (15.6 ml) was added dropwise to 2-chioro-5- nitrobenzonitrile (3.38 g, 18.5 mmol) and SnC12.2H20 (18.9 g, 83.9 mmol, 4.5 eq.) in isopropanol (35 ml). The mixture was heated at 120 C. for 2 h and then cooled to room temperature and made basic using aq. NaOH. The mixture wasextracted with dichloromethane, dried over Na2SO4 and filtered through silica gel. Concentration under reduced pressure gave 5-amino-2-chlorobenzonitrile (2.58 g, 91%).55?H NMR (300 MHz, CDC13): oe=3.90 (br. s, 2H), 6.79 (dm, 1H), 6.91 (m, 1H), 7.22-7.26 (m, 1H) ppm.
The synthetic route of 16588-02-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Maue, Michael; Kapferer, Tobias; Muehlthau, Friedrich August; Malsam, Olga; US9204645; (2015); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts