Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 17216-62-5
(a) Diethyl 2-(2-cyanoethyl)-2-(5-nitropyrid-2-yl)malonate Sodium hydride (53% dispersion in oil) (30.71 g, 0.66 mole) was washed by decantation with xylene (2*150 ml), ether (150 ml), tetrahydrofuran (THF) (150 ml) and finally suspended in THF (245 ml). Diethyl 2-(2-cyanoethyl) malonate (156 g, 0.73 mole) in THF (80 ml) was added dropwise over 1 hr keeping the internal temperature at 18 C. to 22 C. (with ice bath cooling). The resulting suspension cleared over 15 minutes when 2-chloro-5-nitropyridine (88.3 g, 0.55 mole) was added to give a deep magenta solution. The resulting solution was refluxed for 1 hr and the solvent was removed on the rotary evaporator. The resulting oil was partitioned between water (500 ml) and chloroform (800 ml), the pH was adjusted to ~7 (concentrated hydrochloric acid), and the chloroform was run off. The aqueous layer was extracted with a further (2*250 ml) chloroform, the extracts were combined, dried over magnesium sulphate and the solvent was removed to give an amber oil (~245 g). Ether (150 ml) was added and the solution was allowed to crystallise to give the title compound (121.98 g, 65%), m.p. 59.5-61 C. (Found C, 53.7; H. 5.05; N, 12.35%. C15 H17 N3 O6 requires C, 53.75; H, 5.1; N, 12.55%) NMR (CDCl3, 60 MHz); delta 1.37 (6 H, t); 2.65 (4 H, m); 4.26 (4 H, q); 7.84 (1 H, dd); 8.49 (1 H, dd); 9.32 (1 H, dd).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17216-62-5.
Reference:
Patent; Smith Kline & French Laboratories Limited; US4902698; (1990); A;,
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