Application of 59997-51-2,Some common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, molecular formula is C7H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4,4-Dimethyl-3-oxopentanenitrile (80 mmol, 10 g)At room temperature EtOH (200 mL)And stirred at 0 C, hydrazine monohydrate(160 mmol, 7.74 ml) was slowly added. Heated to 90 C and refluxed for 3 hours. After the reaction was completed, the reaction mixture was cooled at room temperature, and the solvent was removed under reduced pressure. Diluted with water, extracted with EtOAc Respectively. Sodium sulfate was added to the extracted organic solvent to remove residual water, and the resultant was separated by MPLC to obtain a red solid Was prepared in a yield of 57%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,4-Dimethyl-3-oxopentanenitrile, its application will become more common.
Reference:
Patent; Korea Research Institute of Chemical Technology; Lee, Kwang Ho; Choe, Gil Don; Park, Sang Jun; Lee, Na Li; Jung, Myung Eun; Kim, Sung Jin; Yang, Kyung Min; Lee, Ji Hee; (28 pag.)KR101726648; (2017); B1;,
Nitrile – Wikipedia,
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