Synthetic Route of 119584-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 119584-73-5, name is 2-Ethoxy-6-fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 8: Synthesis of 3-amino-4-ethoxy-7-methanesulfonylamino- benzo [B] THIOPHENE-2-CARBOXYLIC acid amide To a stirred solution of 2-ethoxy-6-fluorobenzonitrile (J. Hynes, J.Heterocycl.Chem. 1988, 25, 1173) (10. 0 G, 60. 54 mmol) in THF (150mL) at-78C was added lithium diisopropylamide (1. 8 M, 44.1 mL, 79. 4MMOL). The mixture was stirred AT-78 C for lh. Then it was poured slowly onto dry ice and stirred until it reached room temperature. The mixture was concentrated to about 10 mL, then diluted with 6N HCI (200mL), and extracted with dichloromethane (3X100 mL). The solvent was washed with brine and dried over NA2S04. The solvent was removed to give product 3-CYANO-4-ETHOXY-2- fluorobenzoic acid (4.2 g, 33.2%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethoxy-6-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/12283; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts