Electric Literature of 5922-60-1, The chemical industry reduces the impact on the environment during synthesis 5922-60-1, name is 2-Amino-5-chlorobenzonitrile, I believe this compound will play a more active role in future production and life.
General procedure: Under a N2 atmosphere, a Schlenk tube was charged with 2-aminobenzonitrile 1 (0.3 mmol),sodium arylsulfinate 2 (0.6 mmol), Pd(OAc)2 (10 mol percent), bpy (20 mol percent), p-NBSA (10 equiv), THF (2 mL), and H2O (1 mL) at room temperature. The reaction mixture was stirred vigorously at 80 °C for 48 h. The mixture was poured into ethyl acetate, which was washed with saturated NaHCO3 (2 × 10 mL) and then brine (1 × 10 mL). After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products 3.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Chen, Jiuxi; Li, Jianjun; Su, Weike; Molecules; vol. 19; 5; (2014); p. 6439 – 6449;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts