Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75344-77-3, name is 4-Bromo-3,5-dimethylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Bromo-3,5-dimethylbenzonitrile
Under a nitrogen atmosphere, Add the previous step in a 250 ml three-neck round bottom reaction bottle. 10-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-10H-phenoxazine, 420 mg of 4-bromo-3,5-dimethylbenzonitrile, 120 ml of toluene, 40 ml of absolute ethanol and 40 ml of a 2 molar solution of potassium carbonate per liter, Stir and dissolve. After 15 minutes of aeration, 50 mg of tetrakis(triphenylphosphine)palladium(0) catalyst was added, and after aeration for 30 minutes, it was heated to 85 C and refluxed for 24 hours. After the reaction was stopped and the reaction was stopped, the solvent of the reaction system was removed by steaming. The reaction system was extracted with a dichloromethane solvent. It was washed three times with deionized water, three times with saturated brine, and dried over anhydrous magnesium sulfate for 1 hour. Purification of the product by column chromatography, The eluent is a mixed solvent of petroleum ether and dichloromethane in a ratio of 3:1. The yield of the solid product was finally 77%.
According to the analysis of related databases, 75344-77-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; South China University of Technology; Su Shijian; Cai Xinyi; Qiu Weidong; Qiao Zhenyang; (32 pag.)CN108530376; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts