Electric Literature of 939-80-0, The chemical industry reduces the impact on the environment during synthesis 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
3-Nitro-4-(4,4,4-trifluorobutylamino)benzonitrileA mixture of 4-chloro-3-nitro-benzonitrile (1.36 g, 7.43 retool, 1 eq), 4,4,4-trifluorobutan-1-amine (945 rag, 7.43 retool, 1 eq) and triethylamine (1.04 mL, 7.43 retool, 1 eq) inacetonitrile (30 mL) was stirred at room temperature. After 16 h the reaction wasconcentrated in vacuo to dryness. The residue was dissolved in CH2C12 (30 mL), washedwith water (3 x 15 mL), dried (MgSO4), filtered and concentrated in vacuo to yield the titlecompound as a yellow solid (1.99 g, 98%).1H NMR (250MHz, CDC13): c2.10 (m, 2H), 2.33 (m, 2H), 3.51 (q, 2H), 6.95 (d, 1H), 7.68(m, 1H), 8.44 (br.s, 1H), 8.57 (d, 1H). LC/MS 274 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA UK LIMITED; ARROW THERAPEUTICS LIMITED; BLADE, Helen; CARRON, Elisa, Ann; JACKSON, Heather, Marie; LUMLEY, James, Andrew; PILKINGTON, Christopher, John; TOMKINSON, Gary, Peter; THOMAS, Alexander, James, Floyd; WARNE, Justin; WO2010/103306; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts