Adding a certain compound to certain chemical reactions, such as: 874-97-5, name is 3-Cyanobenzyl alcohol, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874-97-5, Product Details of 874-97-5
A mixture of 4 (150 mg, 1.3 mmol), hydroxymethyl-benzonitrile (212 mg, 1.6 mmol), and Triphenyl phosphine (417 mg, 1.6 mmol) dissolved in 7 ml pg THF was charged with DIAD (322 mg, 1.6 mmol) dropwise and stirred at RT for two hours. The crude mixture was then dry-loaded onto silica and purified by ISCO(0-2% MeOH in DCM) to afford 3-((4-nitro-1H-pyrazol-1-yl)methyl)benzonitrile (255 mg, 72% yield). 1H NMR (400 MHz, Chloroform-d) delta 8.14 (d, J = 9.4 Hz, 2H), 7.72 – 7.63 (m, 1H), 7.64 – 7.48 (m, 3H), 5.35 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyanobenzyl alcohol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Pastor, Richard M.; Burch, Jason D.; Magnuson, Steven; Ortwine, Daniel F.; Chen, Yuan; De La Torre, Kelly; Ding, Xiao; Eigenbrot, Charles; Johnson, Adam; Liimatta, Marya; Liu, Yichin; Shia, Steven; Wang, Xiaolu; Wu, Lawren C.; Pei, Zhonghua; Bioorganic and Medicinal Chemistry Letters; vol. 24; 11; (2014); p. 2448 – 2452;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts