Electric Literature of 1009-35-4, The chemical industry reduces the impact on the environment during synthesis 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
To a solution of Intermediate 7 (0.20 g, 0.60 mmol) in THF (15 mL) was addedLiHMDS (1.80 mL, 1.80 mmol) at -78°C. The reaction mixture was stirred at -78°C for15 minutes, followed by dropwise addition of a solution of 4-fluoro-3-nitrobenzonitrile(0.10 g, 0.60 mmol) in THF (5 mL) at -78°C. The reaction mixture was stirred at roomtemperature for 16 h, then quenched with saturated aqueous NH4C1 solution (50 mL) andextracted with EtOAc (100 mL). The organic layer was separated, washed with H20 (100mL) and brine (100 mL), then dried over anhydrous Na2SO4 and concentrated in vacuo.The crude residue was purified by column chromatography (silica 100-200 mesh, 40percentEtOAc in hexanes) to afford the title compound (0.18 g, 64percent) as a yellow solid. LCMS(Method 3, ES+) 479 MH, 3.41 minutes.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UCB BIOPHARMA SPRL; CHARLTON, Rebecca Louise; DE HARO GARCIA, Teresa; LOWE, Martin Alexander; MACCOSS, Malcolm; MORGAN, Trevor; TAYLOR, Richard David; ZHU, Zhaoning; (127 pag.)WO2017/89453; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts