Application of 5332-06-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5332-06-9 as follows.
General procedure: To a stirred solution of N-norhydromorphone (S10 in the SupplementaryMaterials, 0.406 g, 1.5 mmol) in DMF (10 mL) were added NaHCO3 (0.504 g, 6 mmol) and 1-(2-bromoethyl)-4-chlorobenzene (0.480 mL, 3.3 mmol). The mixture was heated at 90 C overnight,cooled to room temperature, filtered through Celite, and concentrated in vacuo. Water (10 mL) wasadded and the mixture extracted with CHCl3 (3 × 20 mL). The combined organics were washed withH2O (5 × 20 mL), dried over Na2SO4, filtered through Celite, and concentrated in vacuo to afford 2ifree base as a crude colorless oil. Purification of this oil by SiO2 column chromatography with 10%NH4OH in MeOH/CHCl3 (gradient, 0 ? 4% of 10% NH4OH) afforded 2i (0.420 g, 70%) as a colorlessoil.
According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Adler, Martin W.; Bergman, Jack; Chadderdon, Aaron M.; Crowley, Rachel Saylor; Geller, Ellen B.; Hanna, Ramsey D.; Hassan, Sergio A.; Herdman, Christine A.; Inan, Saadet; Irvin, Thomas C.; Jacobson, Arthur E.; Kaska, Sophia; Katz, Jonathan L.; Kopajtic, Theresa A.; Lee, Yong-Sok; Paronis, Carol A.; Prisinzano, Thomas E.; Rice, Kenner C.; Traynor, John R.; Wang, Meining; Withey, Sarah L.; Molecules; vol. 25; 11; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts