Synthetic Route of 50594-78-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50594-78-0 name is 5-Fluoro-2-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1 :To a solution of 2-methoxyethanol (9.6 ml_, 122 mmol) in THF at O0C was added NaH (60% in oil, 4.8 g, 122 mmol). The mixture was stirred at O0C for 15 min. To this solution was added 5-fluoro-2-nitrobenzonitrile (15.0 g, 103 mmol). The solution was then allowed to warm to RT and stirred at ambient temperature for 48 hours. The solution was partitioned between EtOAc and water. The water layer was extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated. The crude product was purified via flash chromatography (SiO2: gradient elution, 100:0 to 10:90 hexanes: EtOAc) to afford the ether (21.7 g, 95%) as a light yellow liquid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Fluoro-2-nitrobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; WO2009/5646; (2009); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts