Related Products of 330792-69-3, These common heterocyclic compound, 330792-69-3, name is 2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene (22.5 g) and 1,1-dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene oil (15g) are treated with a solution of hydrazine hydrate (18 mL) in ethanol (25 mL) and heated on the steambath for 1 hour. Ethanol (15 mL) is added followed by water (10 mL). The precipitated solid is collected and washed with ethanol:water (4:1) and then dried in air to give 3-amino-4-cyano-5-(4-phenoxyphenyl)pyrazole as a pale orange solid.
The synthetic route of 330792-69-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pharmacyclics, Inc.; Buggy, Joseph J.; Chang, Betty Y.; US2013/178483; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts