Synthetic Route of 1897-52-5,Some common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-(2-Cyano-3-fluorophenyl)piperazine-l-carboxylic acid tert-butyl ester. In a round bottom flask, sodium hydride (60%) (2.40 g; 60 mmol) was suspended in DMF (25 mL) and cooled in an ice water bath under nitrogen. 1-Boc- Piperazine (9.53 g; 50.6 mmol) was added in small portions to the reaction mixture at 0 C over 30 minutes. The mixture was allowed to stir at room temperature for 3 hours and the recooled to 0 C. 2,6-Difluorobenzonitrile (8.57 g; 60 mmol) was added to the reaction mixture in DMF (10 mL) over 45 minutes. The mixture was stirred at room temperature for 16 hours. The reaction mixture was poured in ice water (250 mL) and stirred. The solid was collected by vacuum filtration and washed
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Difluorobenzonitrile, its application will become more common.
Reference:
Patent; deCODE Chemistry, Inc.; WO2008/16973; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts